Characterization of a Reverse-Phase Perfluorocarbon Emulsion for the Pulmonary Delivery of Tobramycin
نویسندگان
چکیده
منابع مشابه
Characterization of a reverse-phase perfluorocarbon emulsion for the pulmonary delivery of tobramycin.
BACKGROUND Aerosolized delivery of antibiotics is hindered by poor penetration within distal and plugged airways. Antibacterial perfluorocarbon ventilation (APV) is a proposed solution in which the lungs are partially or totally filled with perfluorocarbon (PFC) containing emulsified antibiotics. The purpose of this study was to evaluate emulsion stability and rheological, antibacterial, and ph...
متن کاملEffects of Emulsion Composition on Pulmonary Tobramycin Delivery During Antibacterial Perfluorocarbon Ventilation.
BACKGROUND The effectiveness of inhaled aerosolized antibiotics is limited by poor ventilation of infected airways. Pulmonary delivery of antibiotics emulsified within liquid perfluorocarbon [antibacterial perfluorocarbon ventilation (APV)] may solve this problem through better airway penetration and improved spatial uniformity. However, little work has been done to explore emulsion formulation...
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ژورنال
عنوان ژورنال: Journal of Aerosol Medicine and Pulmonary Drug Delivery
سال: 2014
ISSN: 1941-2711,1941-2703
DOI: 10.1089/jamp.2013.1058